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New high-tech treatments may be able to repair cavities without fillings and even regrow entire teeth.
by David Cox /
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From fluoride toothpaste to dental sealants, science has brought all sorts of tools for fighting tooth decay — and yet 91% of Americans between 20 and 64 years of age are affected by dental caries.

But provocative new research suggests that cell-stimulating medications can “trick” teeth into repairing themselves. If these “small molecule” drugs work as well as scientists think they will, we may be on the cusp of a new era in which dental tissue and even entire teeth can be regrown .

And this is only one of several new approaches that hold promise for tooth regeneration.

Right now, when dentists spot caries, they drill out the decayed material and fill the hole with a cement-like substance called amalgam. But amalgam can fail or even fall out. That can bring more discomfort and a trip back to the dentist.

This could all change. The research shows the drugs can coax stem cells within the dental pulp — the soft material deep within teeth that’s filled with nerves and blood vessels — into regrowing enough bony tissue (dentin) to fill the cavity.

Researchers are especially excited about Tideglusib , a low-cost experimental drug with an established safety record. They think it could be fast-tracked through clinical trials for use to stop tooth decay (Tideglusib is currently being tested for use against Alzheimer’s disease).

“The dentin produced by stimulating stem cells with Tideglusib integrates itself completely within the tooth so there’s no risk of the filling coming out, which is a big problem with the current methods, which haven’t changed much in the past 100 years,” says Dr. Paul Sharpe, professor of stem biology at Kings College London and leader of the research. “There’s a big need for biology to impact upon dentistry and drag it out of the 19th century.”

So far Tideglusib has been studied only in rats, but Sharpe expects to start human trials within the next year. He hopes that it can eventually replace amalgam, which contains mercury. “Mercury works and it lasts for a long time, but having that in your mouth is a concern,” Sharpe says.

Meanwhile, scientists at the University at Buffalo in New York are exploring an even more radical way to regrow teeth. A team led by Dr. Praveen Arany, assistant professor of oral biology at the university, is testing the use of low-power laser light to stimulate tooth regeneration .

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When decay reaches the pulp, dentists perform a root canal. This involves removing the bulk of the tooth and then filling what’s left with amalgam. The tooth is then sealed with an artificial cap, but this can fail over time as a result of the stresses of chewing.

There are no compromises under the hood to achieve the solid battery life. The P20 Pro is packing Huawei’s own Hisilicon Kirin 970 processor, backed by 6GB of RAM with 128GB of storage. We found performance to be fast and smooth in our testing.

The Sony Xperia XZ2 has serious stamina

With a3,180mAh battery the XZ2 doesn’t look specialon paper, but in the real world, we found that it’s capable of outperforming our expectations — going a day and beyond without difficulty. There’s a Snapdragon 845 backed by 6GB of RAM inside, a 5.7-inch Full HD display, and a capable 19-megapixel camera. Sony also offers some handy power management modes in the software. It’s quite expensive at $800, but if you need something that will last for extended periods between outlets, it’s worth considering.

Sony Xperia XZ2 review

The 6.1-inch AMOLED Full HD display is vivid and sharp, and there is an excellent triple main camera that combines 40-megapixel, 8-megapixel, and 20-megapixel sensors. We also like the design, with a small notch at the top of the screen and a slim bezel at the bottom that houses the fingerprint sensor. The P20 Pro runs Android 8.1 Oreo. If we had to find a weakness it would be Huawei’s EMUI user interface and the lack of the headphone port, but this is a great all-around device.

You can check out our roundup of other smartphones with the NewbarK Melanie SquareToe Mules Extremely Cheap Online IT1o5
for other alternatives.

The best budget phone

Nokia 6.1

Julian Chokkattu/Digital Trends

Why should you buy this: You’re on a strict budget, but you still want a powerful phone.

Our Score
The best smartphone under $300
Nokia 6.1
Nokia delivers build quality, battery life, and performance.
$233.10 from Amazon.com

Who’s it for: Bargain buyers who want a steady Android phone.

How much will it cost: $270

Why we picked the Nokia 6.1 :

The Nokia 6.1 offers great build quality, something the Nokia brand has always been associated with. While everyone else turns to glass, the Nokia 6.1 is unashamedly metal and it retains a 16:9 aspect ratio and big bezels around its screen. A dull, dated look is skillfully sidestepped with a series of arresting anodized copper highlights that really make this phone pop.

The 5.5-inch display is Full HD, there’s a respectable Snapdragon 630 processor inside backed by 3GB or 4GB of RAM, depending on whether you opt for the 32GB or 64GB model. There is also a MicroSD card slot for expansion. The 3,000mAh battery goes the distance it recharges via the USB-C port.

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